The best Side of cees dekker
The best Side of cees dekker
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Nanotechnology delivers A selection of alternatives to add to biology. Here I will present examples in which nanofabrication – the chance to make confined buildings with Proportions at will – is made use of to look at the biophysics of one molecules and cells. I'll existing some illustrations from our lab:
Our group experiments bacterial mobile division and is also aiming to constitute a ‘base up biology’ in synthetic cells that may autonomously divide. Our main desire lies in mobile division, chromatin structure, and spatial control.
Back in 1991, Sumio Iijima in the NEC Corporation had noted the synthesis of carbon nanotubes. Band structure calculations advised that these nanotubes could exhibit metallic band conduction. This could be a substantial benefit more than the conducting polymers we had explored, which were, actually, disordered semiconductors providing merely variable-variety hopping conductivity.
Considering the fact that 2000, Dekker has shifted the key concentration of his function in direction of biophysics where by he research the Homes of one biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was driven by his fascination for your impressive performing of Organic molecular structures, in addition to with the very long-time period standpoint that many intriguing discoveries might be predicted With this industry.[five] Current strains of research in his biophysics group are during the parts of:[six]
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The coiled-coil of the human Rad50 DNA maintenance protein is made up of particular segments of amplified versatility
Given that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from DNA supercoiling scientific tests of nucleosomes and DNA mend proteins to DNA translocation by means of nanopores. Lately his research has centered on learning mobile division with microorganisms on chip, whilst his ultimate fascination is inside the direction of noticing synthetic cells.
Atomic pressure microscopy reveals that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative trend
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‘The fantastically delicate way through which factors in nature function hardly ever ceases to amaze me. If we clear up the puzzle of how daily life came into being, I hope that my amazement with the complexity of development will have amplified and with it my awe for that greatness in the Creator.’
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Cees Dekker is Distinguished University Professor at TU Delft. Trained as a physicist, he pioneered nanotechnology with many discoveries on carbon nanotubes in the 1990s. Since 2000, he moved to one-molecule biophysics and nanobiology. His present-day investigate concentrates on (i) nanopores for protein sequencing; (ii) chromosome framework, specifically SMC motor protein; and (iii) creating a living synthetic mobile from lifeless molecules. Dekker is really an elected member with the KNAW and fellow on the APS along with the IOP.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij met enkel-molecuultechnieken de cees dekker biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart style and design in 2005. (nl)